Psilocybin as an antidepressant: research findings

Psilocybin is a psychoactive substance found in several species of mushrooms such as Psilocybe cubensis, Psilocybe semilanceata, and Psilocybe mexicana. It belongs to a group of chemical compounds called tryptamines.

How does psilocybin work?

Psilocybin affects the serotonin system in the brain. It is thought to increase the effects of serotonin in the brain, leading to changes in cognition, mood and consciousness.

research results

A growing number of studies have shown that psilocybin can be effective in treating depression. Here are some of the key research findings:

A 2016 study published in the journal The Lancet Psychiatry showed that psilocybin has beneficial effects in patients with major depression. After a single dose of psilocybin, participants' symptoms improved immediately, and the improvements lasted for up to three months.
Another 2018 study published in the journal Scientific Reports showed that psilocybin may be effective in patients with treatment-resistant depression. The participants received two doses of psilocybin a week apart. The results showed a significant improvement in symptoms among the participants.
A 2020 study published in the journal JAMA Psychiatry showed that psilocybin is safe and well-tolerated in patients with major depression. Participants received two doses of psilocybin a week apart. The results showed a significant improvement in symptoms among the participants.

Legal situation

Psilocybin is illegal in most countries and is considered a controlled substance. However, there are some exceptions, such as the Netherlands, where consumption of psilocybin mushrooms is not illegal.

Official Health Statements

There are no official health claims about psilocybin as an antidepressant. The only health claim authorized by the European Union is: "Serotonin contributes to normal mood and reduces tiredness and fatigue".

conclusion

Psilocybin has the potential to be an effective antidepressant. However, significant research is still needed to study its effectiveness and safety. It's also important to note that psilocybin is a controlled substance and may be illegal.